Comprehensive Cancer Genomics from Blood
Unlocking Cancer’s Genetic Code Through Minimally Invasive Precision Testing
DNA GTx’s TruSight Oncology 500 Liquid Biopsy is an advanced ctDNA-based NGS panel that analyzes 523 cancer-related genes from a simple blood sample. This minimally invasive test detects somatic mutations and genomic alterations associated with solid tumors, providing critical insights to support personalized treatment strategies, especially when tissue samples are limited or unavailable.
Who is this Test for?
- Patients with advanced, metastatic, or inoperable solid tumors
- Individuals who cannot undergo a tissue biopsy due to medical risk or lack of accessible tumor
- Patients whose prior tissue biopsy was insufficient or degraded
- Those needing real-time monitoring of tumor evolution or treatment resistance
- Cases where tissue testing has been done, but additional or updated molecular insights are needed
Variant Types Detected
Single Nucleotide Variants (SNVs)
- SNVs are single base changes between reference and the patient's genome.
Insertions and Deletions (Indels)
- Insertion
- Deletion
- Indels are small changes in DNA where a few bases are either added (insertion) or removed (deletion).
Copy Number Variants (CNVs)
- Amplification / Duplication
- Deletion
- Parts of DNA that are copied too many times or missing. This can make cancer genes overactive or silence protective genes.
Microsatellite Instability (MSI)
- Microsatellites are short, repeated DNA sequences (like “stutters” in the genetic code). Normally, cells fix mistakes in these repeats. If the DNA repair system is broken, the repeats become unstable. It’s an important marker for certain cancers and can predict response to immunotherapy.
Tumor Mutational Burden (TMB)
- TMB is the total number of mutations in a tumor’s DNA. A high TMB means the tumor has many genetic changes, which can make it easier for the immune system to recognize and attack it, and may predict response to immunotherapy.
What it Screens for
- Mutations in 523 cancer-related genes from blood (ctDNA)
- Somatic variants linked to:
- Lung cancer
- Colorectal cancer
- Breast cancer
- Ovarian cancer
- Melanoma
- Other solid tumors
Show list
- Pancreatic cancer
- Prostate cancer
- Bladder cancer
- Gastric (stomach) cancer
- Esophageal cancer
- Endometrial (uterine) cancer
- Thyroid cancer
- Head and neck cancers
- Neuroendocrine tumors
- Soft tissue sarcomas
Can it Be Done After Chemotherapy?
- Yes. The test can be performed after chemotherapy.
- ctDNA testing is often used during or after treatment to:
- Track tumor evolution
- Detect new mutations
- Guide next-line therapies
- However, ctDNA levels may fluctuate post-treatment. Your doctor will decide the best timing based on your care plan.
Key Benefits
- Minimally Invasive Testing: Uses a blood sample—no need for tissue biopsy.
- Comprehensive Mutation Detection: Covers 523 genes to identify key cancer-driving variants.
- Real-Time Tumor Monitoring: Helps track disease progression and treatment response.
- Enables Personalized Therapy: Guides targeted treatment based on tumor genetics.
Turn Around Time
- 5-6 weeks
Do You Need a Doctor’s Request?
Yes. Because this is a complex genomic test with potential implications for treatment, it must be ordered by a physician who will interpret the results in the context of your clinical history and goals of care.
How it Works?
Step 1: Blood Sample Collection
- A blood draw is taken from the patient.
- The sample contains DNA that can reveal important health insights.
Step 2: ctDNA Extraction
- The ctDNA is carefully separated from the rest of the blood.
- These tiny DNA fragments can reveal genetic changes or risks.
Step 3: Library Preparation
- The DNA is prepared so it can be read by our sequencing machines.
- We add special tags and focus on the most important parts of your DNA.
Step 4: Next Generation Sequencing
- This is how we ‘’read’’ your DNA using advanced technology.
- It helps us find changes or mutations in your genes.
Step 5: Data Analysis
- Our proprietary software (D-KRYPT) helps us understand what the DNA changes mean.
- The results are derived from trusted medical databases.
Step 6: Personalized Patient Report
- You got a clear, easy-to-read report with important findings.
- Your doctor can use this to guide treatment or next steps.
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Bring Precision Oncology to the Bloodstream
Designed for patients with advanced or inoperable tumors, it supports real-time monitoring of disease evolution and treatment resistance.
A Simple Blood Test for Cancer Insights
If you’re living with advanced or inoperable cancer—or your doctor recommended a liquid biopsy—reach out today to learn how this test can support your treatment journey.
*All information is handled with strict confidentiality.
