Comprehensive Somatic and Biomarker Profiling
Broad Coverage, Deeper Insights
GTx-500 Plus is designed for comprehensive genomic profiling of solid tumors. This test is an exome-based approach of over 500 cancer-associated genes. It detects key genomic alterations, mutational signatures, and biomarkers such as TMB, and MSI, enabling clinicians to align treatment strategies with the tumor’s molecular profile.
Who is this Test for?
- Patients with solid tumors requiring biomarker-driven treatment planning
- Clinicians seeking an extensive genomic overview to guide targeted therapies or clinical trial enrollment
- Cases where smaller panels may miss key actionable alterations
Variant Types Detected
Single Nucleotide Variants (SNVs)
- SNVs are single base changes between reference and the patient's genome.
Insertions and Deletions (Indels)
- Insertion
- Deletion
- Indels are small changes in DNA where a few bases are either added (insertion) or removed (deletion).
Copy Number Variants (CNVs)
- Amplification / Duplication
- Deletion
- Parts of DNA that are copied too many times or missing. This can make cancer genes overactive or silence protective genes.
Microsatellite Instability (MSI)
- Microsatellites are short, repeated DNA sequences (like “stutters” in the genetic code). Normally, cells fix mistakes in these repeats. If the DNA repair system is broken, the repeats become unstable. It’s an important marker for certain cancers and can predict response to immunotherapy.
Tumor Mutational Burden (TMB)
- TMB is the total number of mutations in a tumor’s DNA. A high TMB means the tumor has many genetic changes, which can make it easier for the immune system to recognize and attack it, and may predict response to immunotherapy.
What it Screens for
- All solid tumors
- Any gene of interest – fully customizable panel (over 500 genes)
- Somatic mutations: SNVs, indels, CNVs
- Tumor mutational burden (TMB)
- Microsatellite instability (MSI)
- Actionable biomarkers for targeted therapy & clinical trials
Key Benefits
- Extensive coverage: Over 500 genes analyzed in one comprehensive assay.
- Exome-based sensitivity: High-confidence detection across variant types.
- Multi-biomarker insight: TMB, MSI reported together for complete molecular context.
- Strategic decision-making: Supports precision treatment planning, trial matching, and translational research.
Turn Around Time
- 5-6 weeks
Do You Need a Doctor’s Request?
Yes. This test must be ordered by a physician, as the results can impact treatment decisions and require clinical interpretation. Your healthcare provider will determine if the test is appropriate based on your cancer type, stage, and treatment plan.
How it Works?
Step 1: FFPE Tissue Sample Collection
- Preserved tissue sample are collected from biopsies or surgeries.
- Stored in wax blocks, these samples keep DNA intact for testing.
Step 2: DNA Extraction
- We carefully extract the DNA from the sample.
- This DNA is what we need to study your genes.
Step 3: Library Preparation
- The DNA is prepared so it can be read by our sequencing machines.
- We add special tags and focus on the most important parts of your DNA.
Step 4: Next Generation Sequencing
- This is how we ‘’read’’ your DNA using advanced technology.
- It helps us find changes or mutations in your genes.
Step 5: Data Analysis
- Our proprietary software (D-KRYPT) helps us understand what the DNA changes mean.
- The results are derived from trusted medical databases.
Step 6: Personalized Patient Report
- You got a clear, easy-to-read report with important findings.
- Your doctor can use this to guide treatment or next steps.
Oncology Test Panels
Clinical Sequencing
Solutions for Researchers
Prenatal Care
Regenerative Medicine
Healthcare
Agriculture
Complete Genomic Clarity for Solid Tumors
GTx-500 Plus delivers broad genomic profiling of over 500 cancer-associated genes with exome-level precision.
Take the Next Step Toward Personalized Cancer Care
Since this test must be ordered by a physician, we’ll connect you with the right support and ensure your healthcare provider has the insights they need for your care.
