Dr. Khodr Issa
医疗总监
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Dr. Issa is the Medical Director at DNA GTx, who drives the integration of clinical genomics and precision medicine, transforming complex molecular data into clinically meaningful solutions. By connecting accredited laboratory practice with translational innovation, he helps shape the future of personalized healthcare.
Books
Issa K. « Hydrogen sulfide, activated Protein C and dexamethasone in Ischemia- Reperfusion / Sulfure d'hydrogène, Protéine C activée et Déxamethasone dans l'Ischémie-Reperfusion”. Presses Academiques Francophones 2013.
Publications
1. Issa K, Kimmoun A, Collin S, Ganster F, Fremont-Orlowski S, Asfar P, Mertes PM, Levy B. Compared effects of inhibition and exogenous administration of Hydrogen Sulfide in Ischaemia-Reperfusion injury. Critical Care. 2013 Jul 10;17(4): R129
2. Kimmoun A, Ducrocq N, Sennoune N, Issa K, Montemont N, Gibot S, Levy B. Efficient extra and intracellular alkalinization improves cardiovascular functions in severe lactic acidosis induced by hemorrhagic shock. Anesthesiology. 2014 Apr;120(4):926-34
3. Issa K, Kettany N, Perrin J, Montemont C, Levy B. Effects of Activated protein C and Dexamethasone in intestinal Ischemia/Reperfusion. Critical Care. 2015
4. Kimmon A, Delemazure J, Dessales N, Djillali A, Fremont S, Ducrocq N, Issa K, Levy B. Beta-1-adrenergic inhibition improves cardiac and vascular functions in experimental septic shock. Critical Care Med. 2015 Sep; 43(9): e332-40.
5. Fardoun M, Nassif J, Issa K , Baydoun E, Eid H.A. Raynaud’s phenomenon: a Brief Review of the Underlying Mechanisms. Front Pharmacol. 2016 Nov 16; 7:438
6. Fardoun M, Al-Shehabi T, El-Yazbi A, Issa K , Zouein F, Maaliki D, Iratni R, Eid H.A. Ziziphus nummularia inhibits inflammation-induced atherogenic phenotype of human aortic smooth muscle cells. Oxid Med Cell Longev. 2017; 2017:4134093
7. Maaliki D, Issa K, Al Shehabi T, Elyazbi A, Eid H.A. « The Role of α2-Adrenergic receptors in Hypertensive Pre-eclampsia: A Hypothesis ». Microcirculation. 2019 Jan;26 (1): e12511
8. Dehaini H, Awada H, El-Yazbi A, Zouein F, Issa K, Eid H.A, Ibrahim M, Badran A, Baydoun E, Pintus G, Eid A. « MicroRNAs as Potential Pharmaco-Targets in Ischemia-Reperfusion Injury Compounded by Diabetes MicroRNAs as Potential Pharmaco-Targets in Ischemia-Reperfusion Injury Compounded by Diabetes ». Cells. 2019 Feb;8 (2), 152
9. Naji S, Issa K, Eid A, Iratni R, Eid H.A. « Cadmium Induces Migration of Colon Cancer Cells: Roles of Reactive Oxygen Species, p38 and Cyclooxygenase-2 ». Cell Physiol and Biochem. 2019 May;52(6):1517-1534
10. Badran A, Baydoun E, Samaha A, Anwar M, Iratni R, Eid H.A and Issa K « Marjoram relaxes rat Thoracic Aorta via a PI3-K/Akt/eNOS/cGMP Pathway ». Biomolecules. 2019 Jun; 9(6): 227.
11. El-Khatib M, Mroueh A, Rafeh R, Sleiman F, Fouad H, Saad E, Fouda M, Elgaddar O, Issa K, Eid H.A, Abd-Elrahman K, El-Yazbi A. « Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of non-obese prediabetic metabolic challenge: Potential role of anti-diabetic drugs ». Translational Research. 2019 Dec; 214:121-143.
12. Fardoun M, Issa K, Maaliki D, A Nasser S, Baydoun E, Eid H.A. « Estrogen Increases Expression of Vascular Alpha 2C Adrenoceptor Through the cAMP/Epac/JNK/AP-1 Pathway and Potentiates Cold-Induced Vasoconstriction ». Vascular Pharmacol. 2020 May; 11;106690
13. Jaber H, Issa K, Eid H.A, Saleh F. « The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice ». Nature research. 2021 March; 11: 6291.
14. Al Zein M, Boukhdoud M, Shammaa H, Mouslem H, El Ayoubi L, Iratni R, Issa K, Khachab M, Assi H, Sahebkar A, Eid H.A. « Immunotherapy and immunoevasion of colorectal cancer ». Drug Discovery Today. 2023 June; 11: 6291.
15. Zedan H, Smatti M, Al-Sadeq D, Nicolai E, Hssain A, Taleb S, Qotba H, Issa K, Abu Raddad L, Althani A, Nasrallah G, Yassine H. « SARS-CoV-2 infection triggers more potent antibody-dependent cellular cytotoxicity (ADCC) responses than mRNA-, vector-, and inactivated virus-based COVID-19 vaccines ». Journal Of Medical Virology. 2024 March
16. Issa K, Fardoun M, Eid H.A. « Cortisol-induced hypertension: a novel role for Rap1, Rho kinase and vascular alpha 2C adrenoceptor». In Preparation *
17. Hamadeh L, Issa K, Eid H.A. « High Glucose Modulates Phenotype of Human Arteriolar Smooth Muscle Cells ». In Preparation *
18. Issa K, Fardoun M, Eid H.A. « Development of a novel protocol for isolation of Human Vascular Smooth Musclar Cells ». In Preparation *
Abstracts
1. Khodr Issa, Ali Eid. Cooling evokes spatial and functional rescue of vascular alpha 2C-Adrenoceptors: Role of ROS, Rho and filamin. British Society of Cell Biology-British Society of Developmental Biology Joint Meeting, University of Warrick, UK; April 2019
2. Manal Fardoun, Khodr Issa, Ali Eid and Elias Baydoun. Estrogen increases expression of human vascular alpha 2C adrenoceptor via the Epac-JNK pathway. British Pharmacological Society; December 2018; London, UK.
3. Lina Hamadeh, Khodr Issa, Ali Eid. High glucose modulates phenotype of human arteriolar smooth muscle cells. British Society of Developmental Biology, University of Warrick, UK; 2018.
4. Rachel Njeim, Khodr Issa and Ali Eid. Alpha-2c Adrenergic Receptor Promotes the Malignant Phenotype of Colon Cancer Cells. ASPET 2018 at the Experimental Biology Meeting.
Poster Presentation
1. Issa K, Fardoun M, SalehA, Samaha A, IratniR, BaydounE, EidA. « The Vasorelaxant Effect of Marjoram in Rat Thoracic Aorta is mediated Via a PI3-K/Akt/eNOS/cGMP Pathway».Kamal A. Shair Central Research Science Laboratory 5 th Research Conference, AUB, Beirut, Lebanon. April 2016
2. Pitris C, Issa K, Stylianou P, Odysseos A. «Quantification of spatiotemporal distribution of the nanoparticles from fluorescence microscopy images of tissue sections». ICoN, Limassol, Cyprus. October 2015
3. Nikos M, Issa K, Odysseos A. «Breaking through the brain tumor barrier». ICoN, Limassol, Cyprus. October 2015
4. Issa K, Christou Y, NarayanA, Stylianou P, Pitris C, Galli R, Odysseos A. «γ-Tocotrienol modulate self-renewal potential in tumors with differential expression of the epidermal growth factor receptor». COST meeting, Athens, Greece. March 2015.
5. Odysseos A, Strongilos A, Davila- Ibanez AB, Stylianou P, Angelou E, Issa K, Iliopoulou S, Maranti A, Othonos KM, Pitris C, Siaugue JM. «Theranostic Silica Core-Shell Nanoparticles Decipher Drug Resistance at the ERB-axis with Nuclear Delivery of Targeted Therapies. Berlin, Germany. March 2015.
6. Kokonou M, Issa K, Siaugue JM, Strongilos A, Agianian B, Stylianopoulos T, Odysseos A. «Resistance to Tyrosine Kinase Inhibitors in solid tumors is managed with nanofiber-based systems for in situ drug delivery». Industrial Technologies 2014. Athens, Greece. April 2014.
7. Issa K, Kettany N, Perrin J, Montemont C, Levy B. «Effects of Activated protein C and Dexamethasone in intestinal Ischemia/Reperfusion». 41th Congress of Reanimation Society of French Languiges SRLF. Paris, France. January 2013.
9. Kimmoun A, Issa K, Ducrocq N, Sennoun N, Montemont C, Gibot S, Levy B. «Bicarbonate with PaCO2 and calcemia normalization does restore cardiovascular performance in severe lactic acidotic rats». 38th Congress of Reanimation Society of French Languiges SRLF. Paris, France. January 2010.
10. Issa K, Collin S, Montemont C, Gibot S, Levy B. « Effects of Hydrogen Sulfide in a rat model of Ischemia Reperfusion ». 38th Congress of Reanimation Society of French Languiges SRLF. Paris, France. January 2010.
11. Issa K, Collin S, Montemont C, Gibot S, Levy B. « Effects of Hydrogen Sulfide in a rat model of Ischemia Reperfusion ». 27th congress of biology and pathology of heart and vessels (GRRC). Nante, France. May 2010.
Podium Presentation
1. Stylianou P, Issa K, Iliopoulou S, Davila- Ibanez AB, Siaugue JM, Stylianopoulos T, Pitris C, Odysseos A «Silica-Coated Core-Shell Nanoparticles define a Novel Theranostic System for Targeted Drug Delivery to Nuclear-Translocated phospho-EGFR» ICoN, Limassol, Cyprus. October 2015
2. Issa K, Dessalles N, Kimmoun A, Strub C, Levy B. « Effets de la modulation β-1 adrénergique sur la cardiopathie septique» 41th Congress of Reanimation Society of French Languiges SRLF. Paris, France. January 2013.
3. Issa K, Collin S, Gibot S, Levy B. « Effects of Hydrogen Sulfide in a rat model of Ischemia/Reperfusion » 38th Congress of Reanimation Society of French Languiges SRLF. Paris, France. January 2010.
4. Issa K, Collin S, Gibot S, Levy B. « Study of a new gasotransmitter, hydrogen sulfide in a model of hemorrhagic shock» One day of research Claude Huriet. Nancy, France. December 2009.
