Integrated Testing for Breast, Ovarian, and Prostate Cancer Risk Management
Detect What You Inherit—and What Develops
DNA GTx’s BRCA Plus Panel provides integrated testing for both germline (inherited) and somatic (acquired) mutations across six key genes associated with breast, ovarian, and prostate cancer risk and progression. By analyzing both types of variants, this panel delivers a more complete genetic profile, supporting personalized prevention, targeted treatment, and informed care planning for patients and families.
Who is this Test for?
- Individuals who need comprehensive BRCA testing, with options to assess inherited (germline) risk or tumor-acquired (somatic) mutations
- You or your doctor need detailed information to decide on targeted treatments
- You have a personal or family history of cancers linked to these genes
- You are considering clinical trials or personalized therapies
Variant Types Detected
Single Nucleotide Variants (SNVs) - Germline / Somatic
- SNVs are single base changes between reference and the patient's genome.
Insertions and Deletions (Indels) - Germline / Somatic
Insertion
Deletion
- Indels are small changes in DNA where a few bases are either added (insertion) or removed (deletion).
Some Copy Number Variants (CNVs) - Germline
Amplification / Duplication
Deletion
- Parts of DNA that are copied too many times or missing. This can make cancer genes overactive or silence protective genes.
What it Screens for
- Germline and somatic mutations in 6 genes, including:
- BRCA1
- BRCA2
- CHEK2
- PALB2
- RAD51C
- TP53
- Linked to:
- Breast cancer
- Ovarian cancer
- Prostate cancer
Key Benefits
- Expanded Risk Assessment: Covers BRCA1/2 plus additional high-risk genes.
- Germline & Somatic Mutation Detection: Identifies inherited and tumor-acquired mutations.
- Supports Prevention & Treatment: Guides both early risk management and targeted therapy.
- Personalized Patient Care: Enables tailored screening, treatment, and family risk planning.
Turn Around Time
- 10 days
Do You Need a Doctor’s Request?
Yes. A healthcare provider must order the test and will explain the results to guide your care.
How it Works?
Step 1: Blood or FFPE Tissue Sample Collection
- A blood draw is taken from the patient.
- Preserved tissue sample are collected from biopsies or surgeries.
- Stored in wax blocks, these samples keep DNA intact for testing.
Step 2: DNA Extraction
- We carefully extract the DNA from the sample.
- This DNA is what we need to study your genes.
Step 3: Library Preparation
- The DNA is prepared so it can be read by our sequencing machines.
- We add special tags and focus on the most important parts of your DNA.
Step 4: Next Generation Sequencing
- This is how we ‘’read’’ your DNA using advanced technology.
- It helps us find changes or mutations in your genes.
Step 5: Data Analysis
- Our proprietary software (D-KRYPT) helps us understand what the DNA changes mean.
- The results are derived from trusted medical databases.
Step 6: Personalized Patient Report
- You got a clear, easy-to-read report with important findings.
- Your doctor can use this to guide treatment or next steps.
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*All information is handled with strict confidentiality.
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Early detection saves lives
*All information is handled with strict confidentiality.
